Derivatives of L-amino acyl L-carnitine, process for their prepa

Details Derivatives of L-amino acyl L-carnitine, process for their prepa Derivatives of L-amino acyl L-carnitine, process for their prepa

1988-11-08

1989-09-19

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514551, A61K 3122

Patent

active

048682110

ABSTRACT:
L-aminoacyl derivatives of L-carnitine of general formula (I) ##STR1## wherein R is an alkyl radical selected from 1-methyl-propyl, isobutyl, isopropyl, mercaptomethyl and 3-guanidino propyl, and their pharmacologically acceptable salts, are prepared e.g. by reacting a solution in an organic solvent of L-carnitine whose carboxyl group is protected with an N-protected aminoacid in the presence of a condensing agent and then removing the amino-acid and carnitine protecting groups, thus obtaining the desired compound.

REFERENCES:
patent: 4401827 (1983-08-01), Witt
patent: 4663352 (1987-05-01), Onofrj

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