Derivatives of isosorbide mononitrate and its use as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S470000, C546S284100, C546S284400, C549S464000, C549S465000

Reexamination Certificate

active

06858632

ABSTRACT:
Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I)in which A and B independently represent any of the groups—ONO2and —Z—CO—R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C1-C4group, an aryl group or an aralkyl group, eventually substituted, or the groupin which R1is hydrogen, or an alkyl C1-C4group, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always —ONO2, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C1-C4group, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group

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