Derivatives of iodothyronine compounds and their use in an assay

Details Derivatives of iodothyronine compounds and their use in an assay Derivatives of iodothyronine compounds and their use in an assay

1981-08-27

1984-01-17

Nucker, Christine M.

Chemistry: analytical and immunological testing

Thyroid hormone tests

436542, 436543, 436544, 436545, 436804, G01N 3358, G01N 3360

Patent

active

044264534

ABSTRACT:
Novel amides of an iodothyronine compound such as tri-iodothyronine (T3) or thyroxine (T4) with an aminoacetic acid compound such as nitrilotriacetic acid (NTA), ethylenediaminetetraacetic acid (EDTA) or diethylenetriamine pentaacetic acid (DTPA) may be labelled, e.g. radioactively labelled with I-125, to give labelled derivatives useful in assays of a free thyroid hormone in a biological fluid which also contains the thyroid hormone bound to one or more natural binders. The novel compound T4 EDTA is shown to bind much more strongly to antibodies to T4 than to the natural protein binders in the biological fluid.

REFERENCES:
patent: 4332784 (1982-06-01), Smith et al.
patent: 4352751 (1982-10-01), Wieder et al.
Kjeld et al., Clinica Chimica Acta, 61 (1975) 381-389.
Radioassay Systems in Clinical Endocienology, Ed. Abraham, Marcel Dekrer, Inc., N.Y., 1979, 101-115.

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