Derivatives of imidazolidin-2-ones and -2-thiones

Details Derivatives of imidazolidin-2-ones and -2-thiones Derivatives of imidazolidin-2-ones and -2-thiones

1975-06-09

1976-09-07

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239B, 2602471M, 2602472A, 2602475F, 260268BC, 26029366, 26029387, 260268N, 2603097, 2603068R, 260566B, 424273, 424267, 427250, C07D40104, C07D40304

Patent

active

039793800

ABSTRACT:
There are disclosed herein derivatives of imidazolidin-2-ones and -2-thiones of the formula I ##SPC1##
and their acid addition salts with pharmacologically acceptable acids, in which R.sup.1 is hydrogen or lower alkyl; R.sup.2 is lower alkyl, nitrothiazolyl, or nitrofuryl; or R.sup.1 and R.sup.2 together with the nitrogen to which they are attached are a heterocyclic group containing 4-6 carbon atoms, or 4 carbon atoms and an additional nitrogen atom which may optionally be substituted with a lower alkyl group, or 4 carbon atoms and an oxygen atom, R.sup.3 is hydrogen or lower alkyl; R.sup.4 is lower alkyl or aralkyl, or R.sup.3 and R.sup.4 together with the carbon atom 5 of the imidazolidine ring to which they are attached are a carbocyclic ring containing 5-6 carbon atoms attached in spiro fashion to said imidazolidine ring; R.sup.5 is lower alkyl or cycloalkyl containing from 5-6 carbon atoms; and X is an oxygen or a sulfur atom. The compounds of this invention possess positive inotropic activity and are useful as cardiac stimulants.

REFERENCES:
patent: 1915334 (1933-06-01), Salzberg et al.
patent: 2075359 (1937-03-01), Salzberg et al.
patent: 2362614 (1944-11-01), Calva
patent: 3115499 (1963-12-01), Michels
Chemical Abstracts vol. 65 cols 8893-94 (1966) Abstracting Lempert et al.
Chemical Abstracts vol. 71 col 12470 (1962) Abstracting Mckay et al.
UGI et al. I "Liebigs Amn. Chem." vol. 666 pp. 54-61 (1963).
UGI et al. II "Angew. Chem." Internat. Ed. vol. 1 pp. 8-21 (1962).

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