Derivatives of imidazo[2,1-b] thiazole

Details Derivatives of imidazo[2,1-b] thiazole Derivatives of imidazo[2,1-b] thiazole

1978-12-11

1980-05-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424270, 548155, C07D27708

Patent

active

042040671

ABSTRACT:
Compounds of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein R, R.sub.1, R.sub.2, R.sub.3, are selected from the group consisting of hydrogen, halogen and lower-alkyl of from one to four carbon atoms, inclusive; with the proviso that taken together they constitute the following substituents on the tetracydic ring, 10-halo, 8,10-dihalo, 8,9-di-lower-alkyl, and 7,9-dilower-alkyl; R', R'.sub.1, R'.sub.2, and R'.sub.3 are selected from the group consisting of hydrogen, halogen and lower alkyl of from one to four carbon atoms, inclusive, with the proviso that when taken together they constitute the following substituents, 1-halo, 2-halo, 3-halo, 4-halo, 1-lower-alkyl, 2-lower-alkyl, 3-lower-alkyl, 4-lower-alkyl, 1,3-dihalo, 2,3-dihalo, 2,4-dihalo, 3,4-dihalo, 1,3-di-lower-alkyl, 2,3-di-lower-alkyl, 1,4-di-lower-alkyl; R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are selected from the group consisting of hydrogen, halogen and lower-alkyl of from one to four carbon atoms, inclusive, with the proviso that when taken together they constitute the following substituents on the tetracyclic ring, 9-halo, 8-halo, 7-halo, 6-halo, 9-lower-alkyl, 8-lower-alkyl, 7-lower-alkyl, 6-lower-alkyl, 7,9-dihalo, 7,8-dihalo, 6,8,-dihalo, 6,7-dihalo, 79-di-lower-alkyl, 7,9-di-lower-alkyl, 7,8-di-lower-alkyl, and 4,6-di-lower-alkyl. R.sub.8 is selected from the group consisting of hydrogen, lower-alkyl of from one to four carbon atoms, inclusive, and R.sub.9 is selected from the group consisting of hydrogen and halo. These compounds are useful as anti-hypertensive agents in mammals.

REFERENCES:
patent: 4014892 (1977-03-01), Spicer et al.
patent: 4059588 (1977-11-01), Baklien et al.
patent: 4110460 (1978-08-01), Baetz
Almirante et al., Jour. Med. Chem. 8, 305 (1965).
Almirante et al., Jour. Me. Chem. 9, 29 (1966).

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