Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-05-26
1990-07-10
Shen, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514269, 514273, 514274, 514826, 514863, 544298, 544316, 544318, A61K 31505, C07D23947, C07D23956, C07D40104
Patent
active
049407120
ABSTRACT:
2-Amino and 2-thio-4-substituted-5-(hydroxy or alkoxy)-pyrimidines, which may be 6-substituted, and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are, therefore, useful for the treatment of pulmonary, inflammatory, dermatological, allergic and cardiovascular diseases. The compounds are also cytoprotective and therefore, useful in the treatment of peptic ulcers.
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Hull, "Synthesis of 5-hydroxypyrimidines", Chemical Abstracts, 51, 3, Abstract No. 1979 (f), (1957).
Melvin Lawrence S.
Walker Frederick J.
DeBenedictis Karen
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
Shen Cecilia
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