Derivatives of glutamic acid and aspartic acid

Details Derivatives of glutamic acid and aspartic acid Derivatives of glutamic acid and aspartic acid

1985-06-18

1988-12-13

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

544176, 546245, 562433, 562443, 564450, C07C12152, A61K 31275

Patent

active

047912154

ABSTRACT:
New derivatives of D,L-glutamic acid and D,L-aspartic acid are described having the formulae: ##STR1## in which n is equal to 1 or 2, R.sub.1 is a phenyl group mono-, di- or tri-substituted with linear or branched C.sub.1 -C.sub.4 alkyl groups, which may be the same or different, or with halogens, with a cyano group or a trifluoromethyl group, and in which R.sub.2 is selected from the group consisting of morpholino, piperidino and amino with one or two linear, branched or cyclic alkyl group substituents containing from 1 to 8 carbon atoms, which may be the same or different, or a pharmaceutically-acceptable salt thereof.
The compounds have an antagonistic activity towards bioactive polypeptides and are useful particularly in the treatment of illnesses of the digestive system and the central nervous system, as pain killers, and for the treatment of anorexia and all those affections (for example tumours) in which exogenous or endogenous bioactive polypeptides are involved.

REFERENCES:
patent: 3551419 (1970-12-01), Re et al.
Unverified English translation of Japanese 14421, 1974.

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