Derivatives of echinocandine, their preparation process and...

Details Derivatives of echinocandine, their preparation process and... Derivatives of echinocandine, their preparation process and...

2007-03-20

2007-03-20

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S002600, C514S011400, C530S317000, C530S318000, C530S300000, C530S333000, C424S009100, C930S270000

Reexamination Certificate

active

11225627

ABSTRACT:
A subject of the invention, in all possible isomer forms as well as their mixtures, is the compounds of formula (I):in whicheither R1: H or CH3andR2: cyclohexyl substituted by an amine, a (CH2)b-C≡N radical or R1and R2together with the nitrogen which carries them form a ring with 3, 4 or 5 carbons optionally substituted by an amineR3: hydrogen, methyl or hydroxylR4: hydrogen or hydroxylR: represents a linear, branched or cyclic chainT: hydrogen, methyl, CH2CONH2, CH2C≡N, a (CH2)2NH2or (CH2)2Nalk+X−radical, X halogen and alk alkylY: hydrogen, hydroxyl, halogen or OSO3H,W: H or OH,Z: H, CH3.The compounds of formula (I) have antifungal properties.

REFERENCES:
patent: 6677429 (2004-01-01), Courtin et al.
patent: 7005417 (2006-02-01), Corbier et al.
patent: WO 96/13272 (1996-05-01), None
patent: WO 99/29716 (1999-06-01), None

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