Derivatives of digoxigenin

Details Derivatives of digoxigenin Derivatives of digoxigenin

1973-09-28

1976-04-27

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 260112R, 424241, C07J 1900

Patent

active

039534316

ABSTRACT:
Derivatives of digoxigenin which are either unlabeled or radioiodinated having the following structural formula: ##SPC1##
Wherein R' is hydroxyl or acetoxy; B is succinyl, phthaloyl, maleyl or fumaryl, preferably succinyl, and X is hydroxyl or alkali metal salt thereof; a protein conjugate; a peptide conjugate; or an amino acid or amnio acid ester radical. The radiolabeled compounds are used in the radioimmunological assay of digoxin. The preferred compound is radioiodinated 3-succinyl digoxigenin-L-tyrosine.

REFERENCES:
patent: 3655643 (1972-04-01), Lehmann et al.
patent: 3855208 (1974-12-01), Rutner et al.
Oliver et al., Jour. Clinical Investigation, Vol. 47, pp. 1035-1042, (1968).

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