Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-08-23
1992-07-07
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514309, 514311, 514314, 514365, 514374, 514376, 514381, 514382, 514397, 514406, 514407, 514414, 514419, 546307, 546309, 546311, 546314, 548181, 548213, 548215, 548225, 548243, 548251, 548252, 548336, 548374, 548454, 548455, 548484, 548491, H01N 4342, C07D20904
Patent
active
051283468
ABSTRACT:
A compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are substituents; R.sub.6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O).sub.2 ; Ar is a heterocyclic group; and n is 1 to 3.
Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.
REFERENCES:
patent: 4568489 (1986-02-01), Floyd
patent: 4634716 (1987-01-01), Parsons et al.
patent: 4665193 (1987-05-01), Ryono et al.
patent: 4668797 (1987-05-01), Urbach et al.
patent: 4877785 (1989-10-01), Hanson et al.
Kerwin James F.
Lin Chun W.
Nadzan Alex M.
Abbott Laboratories
Covington Raymond
Crowley Steven R.
Elder Richard A.
Ivy C. Warren
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