Derivatives of D-glutamic acid and D-aspartic acid

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514309, 514311, 514314, 514365, 514374, 514376, 514381, 514382, 514397, 514406, 514407, 514414, 514419, 546307, 546309, 546311, 546314, 548181, 548213, 548215, 548225, 548243, 548251, 548252, 548336, 548374, 548454, 548455, 548484, 548491, H01N 4342, C07D20904

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051283468

ABSTRACT:
A compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are substituents; R.sub.6 is hydrogen, loweralkyl, cycloalkyl, loweralkenyl, arylalkyl, (substituted aryl)alkyl, or (heterocyclic)alkyl; B is a bond, an alkylene group, an alkenylene group, an alkadienylene group or a heteroatom containing linking group; D is a substituted acyl group or tetrazolyl; Z is CO, C(S) or S(O).sub.2 ; Ar is a heterocyclic group; and n is 1 to 3.
Also disclosed are a composition and a method for antagonizing CCK, a composition and method for treating or preventing gastrointestinal, central nervous, appetite regulating and pain regulating systems, a composition and method for treating or preventing hyperinsulinemia, methods of making the compounds and intermediates useful in making the compounds.

REFERENCES:
patent: 4568489 (1986-02-01), Floyd
patent: 4634716 (1987-01-01), Parsons et al.
patent: 4665193 (1987-05-01), Ryono et al.
patent: 4668797 (1987-05-01), Urbach et al.
patent: 4877785 (1989-10-01), Hanson et al.

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