Derivatives of cyclosporine A, antibodies directed thereto and u

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic

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436518, 436528, 436548, 435 792, 435 793, 435 794, 435 795, 530371, 5303889, G01N 33545

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active

054057850

ABSTRACT:
This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides a composition of matter which comprises a conjugate of a compound and the aforementioned molecule wherein the compound is bound to the molecule through the reactive group. This invention further provides an antibody directed to the aforementioned composition of matter specific for cyclosporine A or congener of cyclosporine A. Finally, this invention provides a method of monitoring levels of cyclosporine A or congener of cyclosporine A in a subject.

REFERENCES:
Quesniaur, et al. (I), Potential of Monoclonal Antibodies Improve Therapeutic Monitoring of Cyclosporine, Clin Chem. 33/1, 1987 pp. 32-37.
Schran et al., Determination of Cyclosporine Concentrations with Monoclonal Antibodies, Clin Chem 33/12, 1987 pp. 2225-2229.
Quesniaux et al. (II), Time Specification & Cross-Reactivity of Monoclonal Antibodiese to Cyclosporine vol. 24, #11 pp. 1159-1168 1987.
Quesnioux et al. (I): "Potential of MAb . . . Cyclosporine" Clin Chem 33/1, 1987 pp. 32-37.
Schran et al. "Determination . . . with MAb" Clin Chem 33/12, 1987 pp. 2225-2229.

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