Derivatives of cyclosporina A, antibodies directed thereto and u

Details Derivatives of cyclosporina A, antibodies directed thereto and u Derivatives of cyclosporina A, antibodies directed thereto and u

1991-05-13

1994-09-27

Kim, Kay K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 530317, 530321, 530345, 530405, 530409, 435961, 435964, 436544, 930270, 930280, A61K 39385, A61K 4100, A61K 3148, C07K 1702, C07K 764, C07K 1706

Patent

active

053505743

ABSTRACT:
This invention provides a molecule comprising cyclosporine A or a congener of cyclosporine A which is photochemically attached to a ligand containing a reactive group. This invention also provides a composition of matter which comprises a conjugate of a compound and the aforementioned molecule wherein the compound is bound to the molecule through the reactive group. This invention further provides an antibody directed to the aforementioned composition of matter specific for cyclosporine A or congener of cyclosporine A. This invention also provides methods for detecting the presence of cyclosporine A or congener thereof, methods for detecting the concentration of cyclosporine A or congener thereof, as well as a method of monitoring levels of cyclosporine A or congener of cyclosporine A in a subject. Finally, this invention provides a method of reducing the amount of endogenous immunoregulatory substances, a method of testing the potential of a pharmalogical agent as an immunoactive agent, as well as a method of testing a pharmalogical agent for immunosuppressive activity.

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