Derivatives of cyclodextrins

Details Derivatives of cyclodextrins Derivatives of cyclodextrins

2006-02-14

2006-02-14

Wilson, James O. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S018700

Reexamination Certificate

active

06998479

ABSTRACT:
The present invention is directed to novel aminooxy-cyclodextrin derivatives of the formula (1): CD—(X—Y—ONH2)n, wherein CD is mono- or polydeoxy α-, β-, or γ-cyclodextrin, carrying in its 6-, 3- and/or 2-position a group containing the aminooxy group, and optionally carrying substituents different from (X—Y—ONH2). Y is a linker group between the aminooxy group and the mono- or polydeoxy-CD group, X is a functional group or an atom necessary to connect the linker Y and the deoxy CD group, or Y is a direct bond when X is a direct bond, and n is ≧1, but ≦24, 21 and 18 for α-, β- or γ-cyclodextrin, respectively, the protected aminooxy derivatives thereof, as well the methods for their preparation and use.

REFERENCES:
patent: A2-9641813 (1996-12-01), None
Nedospasov et al., STN International, No. 5, pp. 1136-1141 (1976), Izv. Akad Nauk SSSR, Ser. Khim (1976), (5) 1136-41.
Varaprasad et al., Bioorganic Chemistry, vol. 14, pp. 8-16 (1986).
Nedospasov et al, STN Internatinal, No. 4, pp. 962-964 (1978), Izv. Akad. Nauk SSSR, Ser. Khim. (1978), (4) 962-4.
AS USSR Molecular et al., WPI/Derwent, No. 88-153418 (1987).
Mortellaro et al., Bioorganic and Medical Chemsitry Letters, vol. 4, No. 16, pp. 2041-2044 (1994).
Hori et al., STN International, pp. 602-608 (1998), Nippo Kagaku Kaishi (1998), (9), 602-608.

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