Derivatives of cyclic ethers and sulfides for the treatment of a

Details Derivatives of cyclic ethers and sulfides for the treatment of a Derivatives of cyclic ethers and sulfides for the treatment of a

1994-03-23

1996-02-13

Datlow, Philip I.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514256, 514365, 514374, 514397, 514406, 514422, 514431, 514432, 514443, 514450, 514456, 514459, 514469, 544333, 544405, 546268, 548204, 548236, 5483151, 5483657, 548561, 5483111, 549 9, 549 13, 549 23, 549 28, 549 57, 549 58, 549355, 549397, 549401, 549425, 549463, 549467, 549 72, 549346, 549487, A61K 3138, A61K 3144, C07D40512, C07D40912

Patent

active

054911524

ABSTRACT:
The present invention provides compounds of Formula I, ##STR1## or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.

REFERENCES:
patent: 4623662 (1986-11-01), DeVries
patent: 4722927 (1988-02-01), Holmes
patent: 4824843 (1989-04-01), Hoefle et al.
patent: 4868210 (1989-09-01), Trivedi
patent: 4882357 (1989-11-01), Creger et al.
patent: 4900744 (1990-02-01), Billheimer et al.
Pfeifer et al, Tetrahedron Letters, 31 (40), pp. 5725-5728 (1990).
Kirby et al, J. Chem. Soc. Chem. Comm. (14), pp. 922-923 (1984).

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