Derivatives of clavulanic acid, a process for their preparation

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

2602453, 542420, C07D49804, A61K 3142

Patent

active

043438075

ABSTRACT:
The compounds of the formula (II): ##STR1## and pharmaceutically acceptable salts and esters thereof wherein X is a C.sub.1-6 alkylene group; m is 1, 2 or 3; n is 1, 2 or 3; A is oxygen, sulphur, --CH.sub.2 -- or --NR.sup.3 -- wherein R.sup.3 is hydrogen, C.sub.1-6 alkyl, phenyl or phenyl (C.sub.1-6)alkyl; R.sup.1 is hydrogen, oxo, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy or phenyl; and R.sup.2 is hydrogen, oxo, C.sub.1-6 alkyl or phenyl: with the proviso that if m and n are both 1 then A is --CH.sub.2 -- and R.sup.2 is not oxo: have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use are described.

REFERENCES:
patent: 3926955 (1975-12-01), Burton et al.
patent: 4229443 (1980-10-01), Bendrup
patent: 4231928 (1980-11-01), Naito et al.
patent: 4237051 (1980-12-01), McCombie
patent: 4244965 (1981-01-01), Howartt
patent: 4246262 (1981-01-01), Vangedal
patent: 4252772 (1981-02-01), Melillo
patent: 4278686 (1981-07-01), Corbett
Brook et al. The Lancet, Feb. 7, 1981, p. 332.
Stirling et al. Chem Abs. 92, 163955d (1979).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Derivatives of clavulanic acid, a process for their preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of clavulanic acid, a process for their preparation , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of clavulanic acid, a process for their preparation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1531160

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.