Derivatives of clavulanic acid, a process for their preparation

Details Derivatives of clavulanic acid, a process for their preparation Derivatives of clavulanic acid, a process for their preparation

1983-03-24

1985-09-03

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

A61K 3500

Patent

active

045392021

ABSTRACT:
The compounds of the formula (II): ##STR1## or pharmaceutically acceptable salts or esters thereof wherein A is a hydrogen atom or an esterifying radical; X is an alkyl group of 1-12 carbon atoms optionally substituted by a hydroxy, amino, acylamino of C.sub.1-6 alkoxy group, which substituents are not on the carbon atom adjacent to the nitrogen atom; or a C.sub.5-7 cycloalkyl group; or a phenylalkyl group wherein the carbon atom content of the alkyl part is 1-6 and the phenyl part is optionally substituted with a fluorine, bromine, chlorine, C.sub.1-6 alkyl, or C.sub.1-6 alkoxy; with the proviso that when X represents an optionally substituted phenylalkyl group and A represents C.sub.1-3 alkyl, then the --CO.sub.2 A group is attached to the alkyl part of the phenylalkyl group; have been found to be .beta.-lactamase inhibitors and antibacterial agents. Their preparation and use is described.

REFERENCES:
Chemical Abstracts 90:168574x, (1978).

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