Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1979-05-08
1981-06-09
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
536 1, 536 3, 536 30, 536 33, 536 43, 536 44, 536 45, 536 48, 536 49, 536 50, 536 54, 536 56, 536 58, 536 59, 536 63, 536 66, 536 84, 536 91, 536 92, 536 96, 536 98, 536102, 536103, 536111, 536115, 536116, 536118, 536120, A61K 31715, C07H 100
Patent
active
042725267
ABSTRACT:
The present invention relates to a chloral derivative having the general formula ##STR1## in which Y' is a polysaccharide consisting of a chain of anhydroglucose, modified anhydroglucose or uronic acid units as substituent group and in which R is selected from --H, --COCH.sub.2 OH, --[(CH.sub.2).sub.n 0].sub..chi. --H in which n is 2 to 5 and .chi. is 1 to 7; --CH.sub.2 OSO.sub.2 X' or --CH.sub.2 COOX' in which X' is NH.sub.4 or a single equivalent of a non-toxic metallic cation, --(CH.sub.2).sub.n H where n is 1 to 7, --(CH.sub.2).sub.n (OH).sub..chi. Y where Y is --H or --CH.sub.3 n is 1 to 7, .chi. is 1 to 12 and the --OH groups are attached to any or all of the carbon atoms by substitution and wherein when Y.sup.1 is a chain of unmodified anhydroglucose units, these units have the following configurations:
REFERENCES:
patent: 2140346 (1938-12-01), Bley
patent: 3221338 (1965-11-01), Segal
patent: 3615649 (1971-10-01), Parish et al.
patent: 3753976 (1973-08-01), Grass et al.
patent: 3878298 (1975-04-01), Parish et al.
Simpkins David E.
Taylor John B. O.
Brown Johnnie R.
Macarthys Pharmaceuticals Limited
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