Derivatives of carboxyalkyl imino- and thioxo-barbituric acids

Details Derivatives of carboxyalkyl imino- and thioxo-barbituric acids Derivatives of carboxyalkyl imino- and thioxo-barbituric acids

1978-04-20

1980-12-02

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

544302, 544320, 544321, C07D23954

Patent

active

042372704

ABSTRACT:
5-Carboxyalkyl-2-iminobarbituric and 5-carboxyalkyl-2-thioxobarbituric acids and derivatives thereof are prepared either by condensation of a triester of a tricarboxylic acid with a thio or imino diamide to yield an ester which is saponified, the desired compound being obtained by liberation with a mineral acid from an ammoniacal medium containing the saponified ester. Alternatively, free tricarboxylic acids may be substituted for the triesters. The compounds described herein have evidenced a therapeutic effect in animals having transplanted tumors, and have inhibited tumor growth and lengthened the life of animals and humans.

REFERENCES:
patent: 2153729 (1939-04-01), Volwiler et al.
patent: 2899435 (1959-08-01), Brandstrom
Johnson et al., Chem. Abstracts, vol. 7 (1913) p. 1701.
Rericha et al., Chem. Abstracts, vol. 45 (1951) col. 8017.

Affiliated with

Also associated with

Rating

Derivatives of carboxyalkyl imino- and thioxo-barbituric acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of carboxyalkyl imino- and thioxo-barbituric acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of carboxyalkyl imino- and thioxo-barbituric acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2285027