Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-01-30
1998-03-24
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 48, C07D49112
Patent
active
057313164
ABSTRACT:
Derivatives of camptothecin are disclosed and are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.15 alkyl group, a C.sub.2 -C.sub.15 alkenyl group or an epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.1 -C.sub.15 alkenyl group or an epoxy group. Processes for making these derivatives and for using them in cancer treatment are also disclosed.
REFERENCES:
patent: Re32518 (1987-10-01), Miyasaka et al.
patent: 3894029 (1975-07-01), Winterfeldt et al.
patent: 4399282 (1983-08-01), Miyasaka et al.
patent: 4473692 (1984-09-01), Miyasaka et al.
patent: 4894456 (1990-01-01), Wall et al.
patent: 4914205 (1990-04-01), Sawada et al.
patent: 4943579 (1990-07-01), Vishnuvajjala
patent: 5053512 (1991-10-01), Wani et al.
patent: 5106742 (1992-04-01), Wall et al.
patent: 5126351 (1992-06-01), Luzzio et al.
patent: 5180722 (1993-01-01), Wall et al.
patent: 5225404 (1993-07-01), Giovanella et al.
patent: 5352789 (1994-10-01), Hinz
patent: 5391745 (1995-02-01), Danishefsky et al.
patent: 5466047 (1995-11-01), Danishefsky et al.
patent: 5525731 (1996-06-01), Danishefsky et al.
patent: 5541327 (1996-07-01), Danishefsky et al.
patent: 5552154 (1996-09-01), Giovanella et al.
patent: 5652244 (1997-07-01), Giovanella et al.
Adamovics, Chem. Abstr. vol. 92 entry 59061 (1980).
Yakult, Chem Abstr vol. 101 entry 91319d (1984).
Yakult, Chem Abstr vol. 101 entry 913222 (1984).
Wu, Chem Abstr vol. 123 entry 52308 1995).
Wu et al., Phytochemistry vol. 39 No. 2, pp. 383-385 May 1995.
Wall and Wani, Nat. Prod. & Drug Dev., Munksgaard, Copenhagen 1984.
Adamovics, Phytochemistry vol. 18 pp. 1085-1086 1979.
Database WPI (Week 8946); AN 89-335912; pp. 1-2; Derwent Publications Ltd., London, GB; XP002033248; Abstract of JP 01 249 777A (Yakult Honsha K. K.) 5 Oct. 1989.
Database WPI (Week 9347); AN 93-374594; pp. 1-2; Derwent Publications Ltd., London, GB; XP002033249; Abstract of JP 05 279 370 A (Daiichi Pharm. Co., Ltd. & Yakult Honsha K.K.) 26 Oct. 1993.
Database WPI (Week 8945); AN 89-329502; pp. 1-2; Derwent Publications Ltd., London, GB: XP002033250; Abstract of JP 01 246 287 A (Yakult Honsha K.K.) 2 Oct. 1989.
J. Med. Chem., vol. 36, No. 18, 1993, pp. 2689-2700, XP000652227 M.E. Wall et al.: "Plant Antitumor Agents. 30, Synthesis and Structure Activity of Novel Camptothecin Analoges."
Fessenden et al., Techniques and Experiments for Organic Chemistry, PWS Publishers, 1983, ISBN 0-8175-0755-2, pp. 56-59.
Van Nostrand's Scientific Encyclopedia 7th Ed. (vol. 1) (1989), pp. 625-627.
McGraw Hill Encyclopedia of Science & Technology, vol. 3, 5th Ed., 1982, pp. 142-146.
Wani et al., J. Med. Chem., vol. 23, pp. 554-560, 1980.
Wani et al., J. Med. Chem., vol. 29 pp. 2358-2363, 1986
Wall et al., J. Med. Chem., vol. 29, pp. 1553-1555, 1986.
Akimoto et al., Journal of Chromatography, vol. 588, pp. 165-170, 1991.
Gunasekera et al., Journal of Natural Products (Lloydia), vol. 42, No. 5, pp. 475-477, 1979.
Sakato et al., Agricultural and Biological Chemistry, vol. 38, No. 1, pp. 217-218, 1974.
Barilero et al., Jour. Chromatog., vol. 575, pp. 275-280 (1992).
Giovanella et al., Science, vol. 246, pp. 1046-1048, Nov. 24, 1989.
Cao Zhisong
Giovanella Beppino C.
Daus Donald G.
The Stehlin Foundation for Cancer Research
LandOfFree
Derivatives of camptothecin and methods of treating cancer using does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of camptothecin and methods of treating cancer using, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of camptothecin and methods of treating cancer using will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2289126