Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1981-05-11
1982-06-08
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424180, 536 71, A61K 3171, C07H 1708
Patent
active
043339255
ABSTRACT:
There are disclosed certain new derivatives of C-076 compounds which have been isolated from the livers of animals that had been administered ivermectin and the in vitro incubation of such compounds with animal liver preparations. The compounds retain the basic ivermectin structure, however, 24-methyl group has been oxidized to a hydroxy methyl group and, in some of the new compounds the disaccharide substituent of the starting materials has been cleaved to a monosaccharide moiety. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
REFERENCES:
patent: 4199569 (1980-04-01), Chabala et al.
patent: 4285963 (1981-08-01), Areson et al.
patent: 4289760 (1981-09-01), Mrozik et al.
Buhs Rudolf P.
Jacob Theodore A.
Miwa Gerald
Sestokas Elena
Taub Rae
Hazel Blondel
Merck & Co. , Inc.
Monaco Mario A.
Rose David L.
LandOfFree
Derivatives of C-076 compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Derivatives of C-076 compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of C-076 compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-552733