Derivatives of biliary acids, process for the production thereof

Details Derivatives of biliary acids, process for the production thereof Derivatives of biliary acids, process for the production thereof

1984-04-24

1986-01-21

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

2603971, A61K 3156

Patent

active

045658102

ABSTRACT:
New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic bile acids having in the side chain in the 19 position a cyclopropane ring are described together with taurine and glycine conjugated derivatives thereof.
The compounds of the invention, prepared from suitable olephinic intermediates by reaction with alkyl diazoacetates or by Simmons-Smith reaction and optional conjugation with taurine or glycine, are endowed with interesting therapeutic properties.

REFERENCES:
Chem. Abstract, vol. 100 (1984) Par. 210,254(v).

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