Derivatives of biliary acids, process for the production thereof

Details Derivatives of biliary acids, process for the production thereof Derivatives of biliary acids, process for the production thereof

1989-10-02

1991-01-01

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Cyclopentanohydrophenanthrene ring system containing

552548, 552549, 552552, C07C 900

Patent

active

049819836

ABSTRACT:
New derivatives of chenodeoxycholic, ursodeoxy cholic, cholic and ursocholic acids, bearing a methyl group in the side chain in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described.
The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.

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patent: 4515786 (1985-05-01), Philibert et al.
patent: 4874754 (1989-10-01), Nigue et al.

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