Derivatives of biliary acids, process for the production thereof

Details Derivatives of biliary acids, process for the production thereof Derivatives of biliary acids, process for the production thereof

1986-07-10

1990-01-09

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514877, 2603971, A61K 31575, C07J 900

Patent

active

048928682

ABSTRACT:
New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic acids, bearing a methyl group in the side chain, in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described.
The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.

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