Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1985-05-10
1987-08-18
Phillips, Delbert R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
564153, C07C12506, C07C10300
Patent
active
046878734
ABSTRACT:
Molecular structures of .beta.-adrenergic antagonists are modified to produce biologically active compounds. The .beta.-antagonists are modified to form molecules of the general structure: ##STR1## wherein R is most generally R"--OCH.sub.2 --, and in some instances is R"--, and R"=an aryl or substituted aryl moiety; R'=--H, --CH.sub.3, or a short chain alkyl moiety; and Y=--OH, or more usually, --OAX or --NHAX, where A=an alkyl, aryl, or aralkyl moiety, and X=a terminal grouping, such as --CH.sub.3, --CF.sub.3 or --(CH.sub.2).sub.n COOH; or AX may be a carrier moiety consisting of a defined peptide or protein.
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Goodman Murray
Marr-Leisy Debra
Melmon Kenneth L.
Rosenkranz Roberto P.
Verlander Michael S.
Phillips Delbert R.
The Regents of the University of California
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