Derivatives of .beta.-adrenergic antagonists

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

564153, C07C12506, C07C10300

Patent

active

046878734

ABSTRACT:
Molecular structures of .beta.-adrenergic antagonists are modified to produce biologically active compounds. The .beta.-antagonists are modified to form molecules of the general structure: ##STR1## wherein R is most generally R"--OCH.sub.2 --, and in some instances is R"--, and R"=an aryl or substituted aryl moiety; R'=--H, --CH.sub.3, or a short chain alkyl moiety; and Y=--OH, or more usually, --OAX or --NHAX, where A=an alkyl, aryl, or aralkyl moiety, and X=a terminal grouping, such as --CH.sub.3, --CF.sub.3 or --(CH.sub.2).sub.n COOH; or AX may be a carrier moiety consisting of a defined peptide or protein.

REFERENCES:
patent: 3949088 (1976-04-01), Samuelsson et al.
patent: 4200652 (1980-04-01), Large et al.
patent: 4337207 (1982-06-01), Goodman et al.
patent: 4396627 (1983-08-01), Ainsworth et al.
Donaruma et al., "Polymeric Drugs"--Academic Press (1978).
Ringsdorf, Journal. of Polymer Science Symposium 51, 135-153 (1975).
Batz, Advances in Polymer Science 4, 25-53 (1977).
Godeau et al., Proc. Nat. Acad. Sciences USA 75, 2353-2357 (1978).
Ringsdorf et al., Die Makromolecular Chemie 177, 741-746 (1976).
Melmon et al., Journ. of Clinical Investigation 53, 22-30 (1974).
Shear et al., Journ. of Bio. Chemistry 251, 7572 7576 (1976).
Pitha et al., Proc. of Nat. Acad. of Science USA 77 2219-2223 (1980).
Verlander et al., Proc. of Nat. Acad. of Sciences USA 73, 1009-1012 (1976).
Venter et al., Polymeric Delivery Systems, Midland Macromolecular Symposium No. 5, 237-250 (1978).
Goodman et al., Jour. of Macromolecular Science Chemistry A13, 52(-543) (1979).
Hu et al., Molecular Pharmacology 14, 237-245 (1977).
Melmon et al., Molecular Pharmacology 12, 701-710 (1976).
Weinstein et al., Jour. of Clinical Investigation 52, 1349-1361 (1973).
Verlander et al., IUPAC International Symposium on Macromolecules, Sep., 1980.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Derivatives of .beta.-adrenergic antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of .beta.-adrenergic antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of .beta.-adrenergic antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1118831

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.