Derivatives of basic polyene macrolides and their preparation

Details Derivatives of basic polyene macrolides and their preparation Derivatives of basic polyene macrolides and their preparation

1990-11-14

1994-05-24

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 181, C07H 1708, C07H 1524

Patent

active

053149998

ABSTRACT:
The present invention relates to basic polyene macrolide derivatives, characterized in that they comprise a basic polyene macrolide which is N-substituted by a 1-amino-1-deoxyketose group which in turn is substituted or unsubstituted, to a process for their preparation and to their use for obtaining drugs.

REFERENCES:
patent: 4195172 (1980-03-01), Falkowski et al.
Polish Journal of Chemistry, vol. 56, 1982, pp. 123-130, L. Falkowski, et al., "The Structure of N-Glycosyl Derivatives of Polyene Macrolide Antibiotics, The Reaction of Nystatin with D-Glucose".
Biochemical Pharmacology, vol. 37, No. 5, 1988, pp. 827-836, M. Cheron, et al., "Quantitative Structure-Activity Relationships in Amphotericin B Derivatives".
Guthrie et al, An Introduction to the Chemistry of the Carbohydrates, 3rd Ed., 1968, Clarendon Press, pp. 73-74.
Falkowski et al., Polish Journal of Chemistry, vol. 56, pp. 123-130 (1982).

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