Derivatives of avermectin and milbemycin

Details Derivatives of avermectin and milbemycin Derivatives of avermectin and milbemycin

1990-07-30

1991-10-08

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, 549264, 536 71, C07D49322

Patent

active

050555960

ABSTRACT:
Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen or optionally protected hydroxy; R.sup.2 is alkoxy, optionally protected hydroxy, oxo or optionally O-substituted oximino; R.sup.3 is hydrogen, optionally protected hydroxy, or a group 4'-(.alpha.-L-oleandrosyl)-.alpha.-L-oleandrosyloxy or .alpha.-L-oleandrosyloxy wherein the terminal hydroxy group is optionally protected; one or R.sup.4 and R.sup.5 is hydrogen and the other is methyl; and one of R.sup.6 and R.sup.7 is hydrogen and the other is methyl; with the proviso that (a) when R.sup.1 is optionally protected hydroxy, R.sup.3 is hydrogen, and (b) when R.sup.2 is not methoxy or optionally protected hydroxy, R.sup.1 and R.sup.3 are both hydrogen, are new and useful as anthelmintic agents.

REFERENCES:
patent: 4285963 (1981-08-01), Arison et al.
J. Antibiotics, 29 (3), 76-14-76-15 (1976).
J. Antibiotics, 29 (6), 76-35-76-42 (1976).

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