Derivatives of asimadoline with covalently bonded acids

Details Derivatives of asimadoline with covalently bonded acids Derivatives of asimadoline with covalently bonded acids

2008-06-10

2008-06-10

McKane, Joseph (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07385065

ABSTRACT:
The present invention relates to derivatives of N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide with covalently bonded acids, and to the salts, solvates and prodrugs thereof, to the derivatives as medicaments, to the use of these derivatives for the preparation of a medicament, to the use of these derivatives for the preparation of a pharmaceutical composition, to a process for the preparation of the pharmaceutical compositions, to pharmaceutical compositions obtainable by this process, and to a process for the treatment of diseases which comprises the administration of the pharmaceutical composition.

REFERENCES:
patent: 4760069 (1988-07-01), Rzeszotarski et al.
patent: 4889860 (1989-12-01), Rzeszotarsi et al.
patent: 5532266 (1996-07-01), Gottschlich et al.
patent: 5585500 (1996-12-01), Drauz et al.
patent: 5776972 (1998-07-01), Barber et al.
patent: 6060504 (2000-05-01), Stein et al.
patent: 6191126 (2001-02-01), Gamache
patent: 6303611 (2001-10-01), Zhang et al.
patent: 6344566 (2002-02-01), Bathe et al.
patent: 6569449 (2003-05-01), Swaan et al.
patent: 2002/0025948 (2002-02-01), Banks et al.
patent: 2003/0036546 (2003-02-01), Clemens
patent: 2005/0176746 (2005-08-01), Weber et al.
patent: 4215213 (1993-11-01), None
patent: 19523502 (1997-01-01), None
patent: 19647538 (1998-05-01), None
patent: 0 569 802 (1993-11-01), None
patent: WO-00/14065 (2000-03-01), None
patent: WO-01/98267 (2001-12-01), None
patent: WO-02/13801 (2002-02-01), None
patent: WO-03/048113 (2003-06-01), None
Cecil Textbook of Medicine, 20th edition (1996), vol. 2, pp. 2050-2057.
Cecil Textbook of Medicine, 20th edition (1996), vol. 2, pp. 1992-1996.
FDA mulls drug to slow late-stage Alzheimer's [online], [retrieved on Sep. 23, 2003]. Retrieved from the Internet, URL; http://www.cnn.com/2003/HEALTH/conditions/09/24/alzheimers.drug.ap/indexhtml>.
Active ingredient [online], [retrieved on Nov. 22, 2006]. Retrieved from the Internet, URL; http://en.wikipedia.org/wiki/Active—pharmaceutical—ingredients>.
Obach, R. Drug-Drug Interactions: An Important Negative Attribute in Drugs. Drugs of Today, 2003, 39, 301-338.
Lupus erythematosus [online], [retrieved on Dec. 28, 2006]. Retrieved from the Internet, URL; http://en.wikipedia.org/wiki/Lupus—erythematosus>.
Lupus [online], [retrieved on Jul. 6, 2007]. Retrieved from the Internet, URL; http://www.nlm.nih.gov/medline/lupus.html>.
Cancer [online], [retrieved on Jul. 6, 2007]. Retrieved from the Internet, URL; http://en.wikipedia.org/wiki/Cancer>.
Cancer [online], [retrieved on Jul. 6, 2007]. Retrieved from the Internet, URL; http://www.nlm.nih.gov/medlineplus/cancer.html>.
Irritable Bowel Syndrome:Tips on Controlling Your Symptoms [online], [retrieved on Jul. 6, 2007]. Retrieved from the Internet, URL; http://familydoctor.org/online/famdocen/home/common/digestive/disorders/112.html>.
Digestive Disorders [online], [retrieved on Jul. 6, 2007]. Retrieved from the Internet, URL; http://familydoctor.org/online/famdocen/home/common/digestive.html>.
Barber et al., British Journal of Pharmacology (Dec. 1994) 113(4):1317-1327.
Barber et al., Expert Opinion on Investigational New Drugs (1997) 6:1351-1368.
Gottschlich et al., Bioorganic & Medicinal Chemistry Letters (Jan. 1994) 4(5):677-682.
Hasler, “Disorders of Gastric Emptying,” in Textbook of Gastroenterology, 3rd edition, Yamada (ed.), 1999, p. 1346.
Johnson, Medical Hypotheses (1995) 45(5):491-497.
Mendelson, American Journal of Psychiatry (2001) 158(6):963-964.
Morley et al., American Journal of Clinical Nutrition (1985) 42(6):1175-1178.
Quigley, Expert Opinion on Pharmacotherapy (2000) 1:881-887.
Non-Final Office Action from U.S. Appl. No. 09/647,813, mailed on Jul. 4, 2001.
Amendment from U.S. Appl. No. 09/647,813, filed Sep. 4, 2001.
Notice of Allowance from U.S. Appl. No. 09/647,813, mailed on Sep. 20, 2001.
Restriction Requirement from U.S. Appl. No. 10/514,887, mailed on Jan. 19, 2006.
Amendment in Response to Non-Final Office Action from U.S. Appl. No. 10/514,887, filed May 19, 2006.
Restriction Requirement from U.S. Appl. No. 10/514,887, mailed on Jun. 30, 2006.
Response to Restriction Requirement from U.S. Appl. No. 10/514,887, filed Jul. 31, 2006.
Non-Final Office Action from U.S. Appl. No. 10/514,887, mailed on Sep. 12, 2006.
Amendment in Response to Non-Final Office Action from U.S. Appl. No. 10/514,887, filed Dec. 12, 2006.
Final Rejection from U.S. Appl. No. 10/514,887, mailed on Mar. 8, 2007.
Amendment After Final Action Under 37 CFR § 1.116, from U.S. Appl. No. 10/514,887, filed Sep. 10, 2007.

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