Derivatives of andrimide and moiramide B having...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S546000

Reexamination Certificate

active

07544709

ABSTRACT:
The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, particularly bacterial infections diseases. The compounds are derivatives of the natural substances andrimide and moiramide B.

REFERENCES:
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patent: 0250115 (1987-06-01), None
patent: 0250115 (1987-12-01), None
patent: 1301657 (1989-12-01), None
Patent Abstracts of Japan; vol. 014, No. 090 (C-0691), JP Application No. 63131043 (Publication No. 01301657).
McWhorter, et al., Stereocontrolled Synthesis of Andrimid and a Structural Requirement for the Activity, J. Chem. Society, Chem. Comm., 5: 299-301 (1989).
Needham, et al., Andrimid and Moiramides A-C, Metabolites Produced in Culture by a Marine Isolate of the BacteriumPseudomonas fluorescens: Structure Elucidation and Biosynthesis, J. Org. Chem., 59(8): 2058-2063, 1994.
Ray, et al., Structures of Cyclic C4H4Radical Cations, J. Am. Chem. Soc.,109: 4408-4411 (1987).
Singh, et al. Biological Activity and Mechanistic Studies of Andrimid, J. Antibiotics, 50 (3): 270-273 (1997).
Davies, et al. Asymmetric Syntheses of Moiramide B and Andrimid, J. Chem. Soc., Perkin Trans. 1, 2635-2643 (1998).

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