Derivatives of amoxicillin

Details Derivatives of amoxicillin Derivatives of amoxicillin

1977-04-27

1978-05-30

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D49968

Patent

active

040923096

ABSTRACT:
Derivatives of amoxicillin having broad spectrum antibacterial activity are disclosed. In addition, the following methods for preparing the compounds are provided (a) reacting the free amino acid amoxicillin or the acid salt or silylated derivative thereof with a reactive derivative of 6-(4-pyridyl)-1,2-dihydro-2-oxonicotinic acid and (b) reacting the free amino acid 6-aminopenicillanic acid or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-(+)-N-(1,2-dihydro-2-oxonicotinyl)-2-(p-hydroyphenyl)glycine.

REFERENCES:
patent: 3873523 (1975-03-01), Doub et al.
patent: 3954734 (1976-05-01), Doub et al.

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