Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-06-08
1981-01-20
Mars, Howard T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602452R, 2602391, 424246, 424267, 424270, 424271, 542416, 542419, 542422, A61K 3133, A61K 31425, C07D49902, C07D50114
Patent
active
042462622
ABSTRACT:
The present invention relates to new 6.beta.-amidino-penicillanic acids of the formula: ##STR1## in which X is oxygen or sulphur, --A-- is aliphatic hydrocarbon, or a single bond, --B-- is aliphatic hydrocarbon, or a single bond; R.sub.1 and R.sub.2 stand for hydrogen, lower alkyl, phenyl or phenyl-lower alkyl; or R.sub.2 is acyl or guanyl; or R.sub.1 and R.sub.2 together with the nitrogen atom can form a monocyclic, saturated ring or represent ##STR2## in which R.sub.3 and R.sub.4 each stands for hydrogen, lower alkyl, phenyl, or phenyl-lower alkyl, or R.sub.3 and R.sub.4 together with nitrogen form a monocyclic, saturated ring; --W-- stands for ##STR3## which represent saturated, monocyclic, bicyclic or spirocyclic ring systems, respectively; salts of the compounds of formula I, and easily hydrolyzable, esters thereof, and salts of such esters; the invention further relating to methods of producing the compounds; to intermediates in their preparation; to pharmaceutical compositions containing the compounds; and to dosage units thereof, and to their use.
The compounds of the present invention are active against a variety of pathogenic microorganisms, including gram-positive and gram-negative bacteria.
REFERENCES:
patent: 3755588 (1973-08-01), Lund
patent: 3957764 (1976-05-01), Lund
Clarke Vera C.
Leo Pharmaceutical Products Ltd. A/S
Mars Howard T.
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