Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-05-26
1980-12-02
Milestone, Norma S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
546237, 2605705C, 2603265S, 2603265SF, 544158, 544399, C07D29510, A61K 31445
Patent
active
042371414
ABSTRACT:
Novel .alpha.-methyl-.beta.-aminopropiophenone derivatives having bronchodilator activity represented by the following general formula: ##STR1## where R represents alkyl having 1-6 carbon atom benzyl or phenyl; R.sub.1 and R.sub.2 individually represent alkyl having 1-6 carbon atom or they form, joining to each other together with the adjacent nitrogen atom with or without intervening an atom other than carbon atom, a saturated heterocyclic ring which may be substituted with lower alkyl; n is an integer of 0, 1 or 2 on the proviso that R represents methyl or ethyl if n is 0, as well as their non-toxic salts are presented. Method of producing the new derivatives and the bronchodilatation method using them are disclosed as well.
REFERENCES:
patent: 3151124 (1964-09-01), Huebner et al.
patent: 3453313 (1969-07-01), Margot et al.
Folia Pharmacol. Japan, vol. 58 (1962), pp. 67-77.
Chemical Abstracts, vol. 86 (1977), 11874q.
Journal of Medicinal Chemistry (1974), vol. 17, No. 8, pp. 819-824.
Journal of Medicinal Chemistry, Nov. (1969), vol. 12, pp. 994-997.
Aoyagi Chiyoko
Furuta Yasuhiko
Hamano Hiroaki
Ikeda Masako
Ishii Yasuo
Milestone Norma S.
Nippon Kayaku Kabushiki Kaisha
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