Derivatives of alpha-methyl benzylamine

Details Derivatives of alpha-methyl benzylamine Derivatives of alpha-methyl benzylamine

1971-10-27

1977-01-18

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465E, 2605011, 260562R, 2605708R, 260592, 260618R, 424304, 424316, 424330, C07C 8728

Patent

active

040039315

ABSTRACT:
New amines having an anti-inflammatory and analgesic activity, represented by the formula: ##STR1## in which X represents a hydrogen or halogen atom such as chlorine, a cyanide or amino group of the formula ##STR2## in which R.sub.1 and R.sub.2 are each a hydrogen atom, or a lower alkyl group, or form with the nitrogen atom a saturated or unsaturated heterocyclic group at C.sub.5 or C.sub.6 which may contain a second hetero atom such as oxygen or nitrogen, n is equal to 1, 2 or 3 and may be equal to 0 when X represents a hydrogen atom, and their addition salts of pharmaceutically acceptable acids.
Method of preparing the above compounds from 3-chloro 4-cyclohexyl acetophenone, which is transformed into 3-chloro 4-cyclohexyl.alpha.-methyl benzylamine, which is then condensed with an amine of the formula X--(CH.sub.2)n -- NH.sub.2, in which X and n are above defined.

REFERENCES:
patent: 3448106 (1969-06-01), Nickl et al.
patent: 3520931 (1970-07-01), D'Ostrowick et al.
patent: 3639423 (1972-02-01), Winter et al.
Roocker et al., "Chemical Abstracts," vol. 59, pp. 9845-9846 (1963).

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