Derivatives of .alpha.-difluoromethylornithine useful in analysi

Details Derivatives of .alpha.-difluoromethylornithine useful in analysi Derivatives of .alpha.-difluoromethylornithine useful in analysi

1981-10-14

1984-02-21

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 4, 435184, 435232, 548303, 549349, 424 3, 436546, 436543, G01N 3350, C12Q 100, C12N 999, C12N 988

Patent

active

044330510

ABSTRACT:
There are provided novel labelled derivatives, namely .alpha.-difluoromethylornithine tagged with rhodamine or with biotin. These are of value in analysis and in the cytochemical localization of enzymes.

REFERENCES:
patent: 2937186 (1960-05-01), Burckhalter et al.
patent: 4134792 (1979-01-01), Boguslavski et al.
Metcalf et al., "Catalytic Irreversible Inhibition of Mammalian Ornithine Decarboxylase by Substrate and Product Analogues", J.A.C.S., vol. 100, No. 8 (1978), pp. 2551-2553.
Gennis et al., "Singlet Energy-Transfer Studies on Associating Protein Systems, Distance Measurements on Trypsin, .alpha.-Chynotrypsin and Their Protein Inhibitors", Biochemistry, vol. 11, No. 13 (1972), pp. 2517-2524.
Gilad, Gad M. et al., "Histochemical Localization of Ornithine Decarboxylase with a Labelled Suicidal Enzyme Inhibitor", Biochemical and Biophysical Research Communications, vol. 96, No. 3, 1980, pp. 1312-1316.

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