Derivatives of A-30912B nucleus

Details Derivatives of A-30912B nucleus Derivatives of A-30912B nucleus

1980-08-25

1981-10-06

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 435 71, C07C10352, A61K 3700, C12P 2104

Patent

active

042934885

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is an N-alkanoyl amino acyl group of the formula ##STR2## wherein: W is a divalent aminoacyl radical of the formula: ##STR3## wherein A is C.sub.1 -C.sub.10 alkylene or C.sub.5 -C.sub.6 cycloalkylene; ##STR4## wherein R.sup.3 is hydroxymethyl, hydroxyethyl, mercaptomethyl, mercaptoethyl, methylthioethyl, 2-thienyl, 3-indolemethyl, phenyl, benzyl, or substituted phenyl or substituted benzyl in which the benzene ring thereof is substituted with chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkylthio, carbamyl, or C.sub.1 -C.sub.3 alkylcarbamyl; ##STR5## wherein X is hydrogen, chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, mercapto, C.sub.1 -C.sub.3 alkylthio, carbamyl, or C.sub.1 -C.sub.3 alkylcarbamyl; ##STR6## wherein X.sup.1 is chloro, bromo, or iodo; ##STR7## wherein B is a divalent radical of the formula: --(CH.sub.2).sub.n --, wherein n is an integer from 1 to 3; ##STR8## and R.sup.2 is C.sub.1 -C.sub.17 alkyl or C.sub.2 -C.sub.17 alkenyl; have anti-fungal activity.

REFERENCES:
patent: 3150059 (1964-09-01), Kleinschmidt et al.
patent: 3978210 (1976-08-01), Mizuno et al.
patent: 4024245 (1977-05-01), Hoehn et al.
patent: 4024246 (1977-05-01), Higgens et al.
patent: 4050989 (1977-09-01), Kuwana et al.
patent: 4173629 (1979-11-01), Dreyfuss et al.
T. Kato et al., J. Antibiotics 29(12), 1339-1340, (1976).
S. Chihara et al., Agr. Biol. Chem. 37(11), 2455-2463, (1973).
S. Chihara et al., Ibid, 37(12), 2709-2717, (1973).
S. Chihara et al., Ibid. 38(3), 521-529, (1974).
S. Chihara et al., Ibid. 38(10), 1767-1777, (1974).
T. Suzuki et al., J. Biochem. 56(4), 335-343, (1964).
J. M. Weber et al., J. Antibiotics 31(4), 373-374, (1978).
J. Shoji et al., J. Antibiotics 28, 764-769, (1975).
J. Shoji et al., Ibid. 29(4), 380-389, (1976).
J. Shoji et al., Ibid. (12), 1268-1274, (1976).
J. Shoji et al., Ibid. (12), 1275-1280, (1976).
F. Benz et al., Helv. Chim. Acta. 57, 2459, (1974).
C. Keller-Juslen et al., Tetrahedron Letters, 4147-4150, 1976, vol. 46.
R. Traber et al., Helv. Chim. Acta. 62, 1252, (1979).

Affiliated with

Also associated with

Rating

Derivatives of A-30912B nucleus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of A-30912B nucleus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of A-30912B nucleus will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1206125