Derivatives of A-21978C cyclic peptides

Details Derivatives of A-21978C cyclic peptides Derivatives of A-21978C cyclic peptides

1985-09-25

1986-12-16

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C07K 512

Patent

active

RE0323110

ABSTRACT:
A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is hydrogen, a specified aminoacyl or N-alkanoylaminoacyl group, 8-methyldecanoyl, 10-methyldodecanoyl, 10-methylundecanoyl, the specific C.sub.10 -alkanoyl group of A-21978C.sub.0 or the specific C.sub.12 -alkanoyl groups of A-21978C factors C.sub.4 and C.sub.5 or an amino-protecting group; and R.sup.1 is hydrogen, an amino-protecting group, or a specified aminoacyl or N-alkanoylaminoacyl group; provided that, when R is other than aminoacyl or N-alkanoylaminoacyl, R.sup.1 must be aminoacyl or N-alkanoylaminoacyl; and, when R.sup.1 is an amino-protecting group, R must be aminoacyl or N-alkanoylaminoacyl; and the salts thereof, are useful as antibacterial agents or as intermediates to antibacterial agents.

REFERENCES:
patent: 3150059 (1964-09-01), Kleinschmidt et al.
patent: 4050989 (1977-09-01), Kuwana et al.
patent: 4208403 (1980-06-01), Hamill et al.
patent: 4293482 (1981-10-01), Abbott et al.
patent: 4293483 (1981-10-01), Debono
patent: 4293485 (1981-10-01), Debono
patent: 4293487 (1981-10-01), Debono
patent: 4293488 (1981-10-01), Debono
patent: 4293491 (1981-10-01), Debono
J. Shoji et al., ibid. 29 (12) 1268-1274, 1275-1280 (1976).
D. Storm et al., "Polymyxin and Related Antibiotics," Ann. Rev. Biochem. 46: 731-732 (1977).
J. M. Weber et al., J. Antibiotics 31 (4) 373-374 (1978).
J. Shoji et al., ibid. 28, 764-769 (1975).
J. Shoji et al., ibid. 29 (4) 380-389 (1976).
S. Chihara et al., ibid. 38 (3), 521-529 (1974).
S. Chihara et al., ibid. 38 (10) 1767-1777 (1974).
T. Suzuki et al., J. Biochem. 56 (4) 335-343 (1964).
T. Kato et al., J. Antibiotics 29 (12) 1339-1340 (1976).
S. Chihara et al., Agr. Biol. Chem. 37 (11) 2455-2463 (1973).
S. Chihara et al., ibid. 37 (12) 2709-2717 (1973).

Affiliated with

Also associated with

Rating

Derivatives of A-21978C cyclic peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Derivatives of A-21978C cyclic peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Derivatives of A-21978C cyclic peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-236247