Derivatives of A-21978C cyclic peptides

Details Derivatives of A-21978C cyclic peptides Derivatives of A-21978C cyclic peptides

1985-09-23

1986-12-16

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

C07K 512

Patent

active

RE0323101

ABSTRACT:
A-21978C cyclic peptide derivatives of the formula ##STR1## wherein R is a substituted benzoyl group of the formula ##STR2## R.sup.2 is C.sub.8 -C.sub.15 alkyl; X is hydrogen, chloro, bromo, iodo, nitro, C.sub.1 -C.sub.3 alkyl, hydroxy, C.sub.1 -C.sub.3 alkoxy, or C.sub.1 -C.sub.3 alkylthio; and R.sup.1 is hydrogen or an amino-protecting group; and the salts thereof, are useful new semisynthetic antibacterial agents or intermediates to such agents.

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S. Chihara et al., Agr. Biol. Chem. 37 (11) 2455-2463 (1973).
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T. Suzuki et al., J. Biochem. 56 (4) 335-343 (1964).
J. M. Weber et al., J. Antibiotics 31 (4) 373-374 (1978).
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J. Shoji et al., ibid. 29 (4) 380-389 (1976).
J. Shoji et al., ibid. 29 (12) 1268-1280 (1976).
D. Storm et al., "Polymyxin and Related Antibiotics," Ann. Rev. Biochemistry 46:731-732 (1977).

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