Derivatives of...

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2007-06-26

2007-06-26

Witherspoon, Sikarl A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Sulfonic acids or salts thereof

C514S517000, C514S553000

Reexamination Certificate

active

10521171

ABSTRACT:
The invention relates to the bis-hydrochloride of 4,4′-dithiobis-(3-aminobutane-1-sodium sulphonate) and the bis-trifluoracetate of 4,4′-dithiobis-(3-aminobutane-1-sulphonate of 2,2-dimethylpropyl). The invention also relates to a pharmaceutical composition comprising one of said compounds and to the use of one of said compounds for the production of a medicament. The invention is suitable for use in a treatment method for hypertension and indirectly- or directly-linked illnesses.

REFERENCES:
patent: WO 99/36066 (1999-07-01), None
Chauvel, et al, “Investigation of the active site of aminopeptidase a using a series of new thiol-containing inhibitos”. J. Med. Chem. (1994). 37(9):1339-1346.
Chavel, et al, “Differential inhibition of aminopeptidase A and aminopeptidase N by New β-amino thiols”. J. Med. Chem. (1994). 37(18):2950-2957.
Database Caplus. Database accession No. 1998:505738; Martin, et al, “β-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain”. American Chemical Society. (1998) RN 213488-11-0.
Martin, et al, “β-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain”. J. Med. Chem. (1998). 41(18):3450-3460.

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