Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-11-14
2006-11-14
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S328000
Reexamination Certificate
active
07135474
ABSTRACT:
This application relates to compounds of the formula (I)in which R1is chlorine, cyano, trifluoromethyl or methoxy and R2is hydrogen or flurorine; or R1and R2are both fluorine; and to pharmaceutically acceptable salts of these materials. Pharmaceutical compositions containing these materials, and methods of using them in treatment of hypertension and sexual dysfunction are also disclosed and claimed.
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Carvajal et al., Molecular Mechanism of cGMP-Mediated Smooth Muscle Relaxation, Journal of Cellular Physiology, 184:409-420, 2000.
Yamashita et al., Mechanisms of Reduced Nitric Oxide/cGMP-Mediated Vasorelaxation in Transgenic Mice Overexpressing Endothelial Nitric Oxide Synthase, Hypertension, 36:97-102, 2000.
Bischoff Erwin
Münter Klaus
Stahl Elke
Stasch Johannes-Peter
Weigand Stefan
Bayer Healthcare AG
Rao Deepak
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