Derivatives of 6-methyl-2H-pyran-2,4(3H)-dione

Details Derivatives of 6-methyl-2H-pyran-2,4(3H)-dione Derivatives of 6-methyl-2H-pyran-2,4(3H)-dione

1973-05-24

1976-06-15

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260302H, 2603096, 260310R, 26032636, 2603403, 2603405, 424245, 424269, 424270, 424272, 424274, 424275, 424279, 260307R, 2603322H, C07D30930

Patent

active

039637565

ABSTRACT:
New compounds of the formula ##SPC1##
Wherein Ar is selected from the group consisting of phenylethyl, furyl, methylfuryl, thienyl, pyrrolyl, naphthyl, hydroxynaphthyl, and phenyl substituted by at least one member selected from the group consisting of halogen, hydroxyl, cyano, trifluoromethyl, akyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, carbamoyl, amino of the formula --NR'R", alkoxycarbonyl of the formula --CO--OR' wherein R'and R"are each alkyl of 1-4 carbon atoms, and alkylenedioxy of the formula --O--R '"--O-- wherein R'" is alkylene of 1-4 carbon atoms, provided that said substituted phenyl is not 3,4-di-methoxyphenyl, and the addition salts thereof with the cation of an organic or inorganic base inhibit the enzyme activities of tyrosine hydroxylase and dopamine .beta.-hydroxylase and are useful chemotherapeutic agents in the treatment of essential hypertension.

REFERENCES:
patent: 3634458 (1972-01-01), McIntyre
Miyaki et al., as cited in CA, 50; p. 980e, (1956).
Walker, J.A.C.S. 78 pp. 3201-5 (1956).
Wiley et al., JACS 77, pp. 5102-5105 (1955).

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