Derivatives of 6.beta.-hydroxyalkylpenicillanic acids as .beta.-

Details Derivatives of 6.beta.-hydroxyalkylpenicillanic acids as .beta.- Derivatives of 6.beta.-hydroxyalkylpenicillanic acids as .beta.-

1979-10-22

1981-09-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

424271, 2602452R, 424246, C07D49900

Patent

active

042871816

ABSTRACT:
6.beta.-Hydroxyalkylpenicillanic acids and derivatives thereof as useful enhancers of the effectiveness of several .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria, and 6.beta.-substituted penicillanic acid benzyl ester derivatives as useful intermediates leading to said agents which enhance the effectiveness of .beta.-lactam antibiotics.

REFERENCES:
patent: 4053468 (1977-10-01), Holden
patent: 4093625 (1978-06-01), Commons et al.
patent: 4123539 (1978-10-01), DiNinno
patent: 4143046 (1979-03-01), Sheehan et al.
DiNinno et al., J. Org. Chem., vol. 42, 2960, (1977).
Sheehan et al., J. Org. Chem., vol. 39, 1444, (1974).
Roets et al., J. Org. Chem. Soc., Perkin I, 704, (1976).

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