Derivatives of 6-aminooctahydroindolizinetriol

Details Derivatives of 6-aminooctahydroindolizinetriol Derivatives of 6-aminooctahydroindolizinetriol

1990-06-04

1992-01-07

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546183, A61K 31435, C07D22100

Patent

active

050792547

ABSTRACT:
Amide and ester derivatives of 6-amino-octahydro-1,7,8-indolizinetriol are described herein. The compounds are prepared from castanospermine by replacing the appropriate hydroxy function with an amino function while protecting the other hydroxy groups in the meantime. The compounds are useful as hexosaminidase inhibitors.

REFERENCES:
patent: 4871747 (1989-10-01), Kinast et al.
Fleet et al., Chem. Letters, 1986, 1051.
Boshagen et al., Carbohydrate Research, 164, 141 (1987).
Derwent Patent Abstract 86-247631 (1986)(Abstract of Japanese Kokai 61 129182).

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