Derivatives of 5-pentylamino-5-oxopentanoil and 4-pentlamino-4-o

Details Derivatives of 5-pentylamino-5-oxopentanoil and 4-pentlamino-4-o Derivatives of 5-pentylamino-5-oxopentanoil and 4-pentlamino-4-o

1988-12-07

1990-01-02

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

548492, C07D20912, A61K 31405, A61K 3140

Patent

active

048913812

ABSTRACT:
New original derivatives are described of 5-pentylamino -5-oxopentanoic and 4-pentylamino-4-oxobutanoic acids having the formula: ##STR1## in which n is 1 or 2, R.sub.1 is selected from the groups 2-naphthyl, 2 (or 3)-quinolinyl, 2 (or 3)-indolyl, 2 (or 3)-benzofuranyl, 2 (or 3)-benzothiophenyl, and R.sub.2 is a pentyl group or an alkoxyalkyl group with 4 or 5 carbon atoms, preferably pentyl, 2-ethoxyethyl, 3-methoxypropyl or 3-ethoxypropyl.
The compounds have a powerful antagonistic activity towards cholecystokinin and are particularly useful in the treatment of illnesses of the digestive system, such as colitis, biliary diskinesia, pancreatitis or in the treatment of disorders of the central nervous system imputable to deficiencies in the physiological neuron levels of cholecystokinin or other related bioactive polypeptides.

REFERENCES:
patent: 4814375 (1989-03-01), Ohlendorf et al.

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