Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-

Details Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4- Derivatives of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-

1988-12-07

1990-01-02

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514469, 549 57, 549468, A61K 31385, C07D33356, C07D30778

Patent

active

048913839

ABSTRACT:
New original derivatives are described of 5-pentylamino-5-oxopentanoic and 4-pentylamino-4-oxobutanoic acids having the formula: ##STR1## in which n is 1 or 2, R.sub.1 is selected from the groups 2-naphthyl, 2 (or 3)-quinolinyl, 2 (or 3)-indolyl, 2 (or 3)-benzofuranyl, 2 (or 3)-benzothiophenyl, and R.sub.2 is a pentyl group or an alkoxyalkyl group with 4 or 5 carbon atoms, preferably pentyl, 2-ethoxyethyl, 3-methoxypropyl or 3-ethoxypropyl.
The compounds have a powerful antagonistic activity towards cholecystokinin and are particularly useful in the treatment of illnesses of the digestive system, such as colitis, biliary diskinesia, pancreatisis or in the treatment of disorders of the central nervous system imputable to deficiencies in the physiological neuron levels of cholecystokinin or other related bioactive polypeptides.

REFERENCES:
patent: 4808599 (1989-02-01), Dubroeucq et al.
patent: 4826878 (1989-05-01), Makovec et al.

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