Derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 72, A61K 3146, C07D47108

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active

048700797

ABSTRACT:
Fluoro-and hydroxy-derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines wherein the substituents are on non-benzenoid carbons are active anticonvulsants and antagonists of N-methyl-D-aspartate.

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Dagani, "New Anticonv. Agents Have Unusual Struct.", Chem. & Eng. News, Sep. 29 (1986).
Meldrum, "Poss. Ther. Appl. of Antag. of Excitatory Amino Acid Neurotrans.", Clin. Sci., 68, pp. 113-122 (1985).
Rothman, "Excitotoxicity & NMDA Receptor", TINS, vol. 10, No. 7 (1987).
Klockgetner et al., Chem. Abstracts, vol. 106 (1987), entry 169537y.

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