Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-03-30
1989-09-26
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 72, A61K 3146, C07D47108
Patent
active
048700797
ABSTRACT:
Fluoro-and hydroxy-derivatives of 5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines wherein the substituents are on non-benzenoid carbons are active anticonvulsants and antagonists of N-methyl-D-aspartate.
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Meldrum, "Poss. Ther. Appl. of Antag. of Excitatory Amino Acid Neurotrans.", Clin. Sci., 68, pp. 113-122 (1985).
Rothman, "Excitotoxicity & NMDA Receptor", TINS, vol. 10, No. 7 (1987).
Klockgetner et al., Chem. Abstracts, vol. 106 (1987), entry 169537y.
Britcher Susan F.
Lyle Terry A.
Thompson Wayne J.
Varga Sandor L.
DiPrima Joseph F.
Merck & Co. , Inc.
Nicholson William H.
Rozycki Andrew G.
Shah Mukund J.
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