Derivatives of 5-(indol-3-yl)hydantoin

Details Derivatives of 5-(indol-3-yl)hydantoin Derivatives of 5-(indol-3-yl)hydantoin

1977-04-18

1978-08-29

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

26029361, 548309, 42424854, 424267, 424273R, C07D41314, A61K 31535

Patent

active

041105362

ABSTRACT:
Derivatives of 5-(indol-3-yl)hydantoin characterized by the generic structural formula, ##STR1## and their pharmacologically compatible salts are useful in the treatment of cardiac arrythmias in individuals for whom such therapy is indicated. In the preceding structural formula, A is a hydrogen atom, a halogeno, alkyl, hydroxyl, or an alkoxyl radical; n is 0 or 1; R is a hydrogen atom or a phenyl group; X is a methylene, ethylene, trimethylene, or 2-hydroxytrimethylene radical; and Z is a monoalkylamino radical containing 1-4 carbon atoms, a dialkylamino radical containing 2-8 carbon atoms, a morpholino, piperid-1-yl, 4-phenyl-piperid-1-yl, or a 4-hydroxy-4-phenyl-piperid-1-yl radical.

REFERENCES:
patent: 3560495 (1971-02-01), Frankus et al.

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