Derivatives of 5-carbamoyloxymethyl-3-substituted-2-oxazolidinon

Details Derivatives of 5-carbamoyloxymethyl-3-substituted-2-oxazolidinon Derivatives of 5-carbamoyloxymethyl-3-substituted-2-oxazolidinon

1976-03-03

1979-03-13

Rush, Raymond V.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

260307C, 424250, 424272, C07D26324, C07D29520

Patent

active

RE0299340

ABSTRACT:
A compound of the formula ##STR1## [in which R is H, halogen, alkyl having 1 to 4 carbon atoms or trifluoromethyl, and R.sub.1 and R.sub.2 each is H or dialkylaminoalkyl or together with N comprise methylpiperazino.] in which (1) ##STR2## is -NH.sub.2 and R is H, m-CH.sub.3, o-CF.sub.3, m-Cl, p-Cl, m-Br, m-F, p-F, o-F, p-CH.sub.3 or m-CH.sub.3, or ##STR3## and R is H, m-CF.sub.3 or m-F, or ##STR4## and R is H, m-CF.sub.3 or m-F.
The compound is prepared by treating the corresponding 5-hydroxymethyl compound with ammonia or an amine in the presence of phosgene.
The compounds possess anti-depressive, myorelaxing, tranquilizing, sedative, analgesic, anti-convulsive, anti-pyretic, anti-inflammatory and uricosuric activities.

REFERENCES:
patent: 3641036 (1972-02-01), Fauran et al.
Morrison et al., "Organic Chemistry," Allyn and Bacon, 1959, p. 692.

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