Derivatives of 5,9-methanocycloocta[b]pyridin-2-(1H)-one,...

Details Derivatives of 5,9-methanocycloocta[b]pyridin-2-(1H)-one,... Derivatives of 5,9-methanocycloocta[b]pyridin-2-(1H)-one,...

2008-11-28

2011-11-08

Havlin, Robert (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S295000

Reexamination Certificate

active

08053577

ABSTRACT:
A compound of Formula I, a pharmaceutically-acceptable salt or a hydrate thereof, wherein R1is H, or C1-4alkyl; R2is H, halogen, or C1-4alkyl; R3is H, halogen, or C1-4alkyl, and R4is C1-6alkyl, aryl; or ═CR3R4is cyclopentylidene, cyclohexylidene, 1-methylpiperidin-4-ylidene, or inden-1-ylidene; R5is independently at each occurrence F, Cl, Br, CF3, R9, OR9, NR9R10, NO2, CN, COOR9, O2CR9, CONR9R10, NR9C(O)R10, heterocyclic group, aryl, or a group of Formula II; R6is H, halogen, or C1-4alkyl; R7is H, halogen, or C1-4alkyl; R8is H, C1-4alkyl group; R9is H, or C1-6alkyl; R10is H, or C1-6alkyl; R11is H, or C1-4alkyl; R12is H, or C1-4alkyl; m is 0, 1, or 2; when R5is F, Cl, Br, CF3, R9, OR9, NR9R10, NO2, CN, COOR9, O2CR9, CONR9R10, NR9C(O)R10, heterocyclic group, or aryl, n is 1, 2, 3, or 4; when R5is the group of Formula II, n is 0, 1, 2, 3, or 4; x is 0, 1, 2, 3, or 4.

REFERENCES:
patent: RE38460 (2004-03-01), Zhu et al.

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