Derivatives of 4-phenyl-4-oxobuten-2-oic acid, pharmaceutical co

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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560 53, 549362, 514568, 514545, 562463, C07C 5990

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active

045007314

ABSTRACT:
A compound of the formula I: ##STR1## in which R.sub.1 and R.sub.2 in any position on the benzene ring are different from each other, and independently represent a hydroxy group or an alkoxy group containing from 1 to 8 carbon atoms, or else R.sub.1 and R.sub.2 together form an --OCH.sub.2 CH.sub.2 O-radical, and R represents a hydrogen atom or an alkyl group containing from 1 to 8 carbon atoms, as well as the alkali metal, alkaline earth metal, ammonium or amine salts of the said products of formula I in which R represents a hydrogen atom. These compounds have been found useful in the treatment of hyperchlorhydria, gastric and gastro-duodenal ulcers, gastritis, hiatal hernias, and gastric and gastro-duodenal ailments accompanied by gastric hyperacidity. Pharmaceutical compositions including these compounds are disclosed along with methods for their production.

REFERENCES:
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Pettit, George R., et al., "Bufadienolides. 1. Introduction and Base-Catalyzed Condensation of Methyl Ketones with Glyoxylic Acid", Journal of Organic Chemistry, vol. 235, No. 5, May 1970, pp. 1367-1376.
Rice, Grace Potter, "The Isomeric Esters of Para-Ethoxy-Benzoylacrylic Acid", J.A.C.S., vol. 46, No. 10, Oct. 1924, pp. 2319-2326.
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