Derivatives of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole

Details Derivatives of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole Derivatives of 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole

1981-03-09

1982-08-31

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2603261, 26032613A, 548342, 549 72, 562460, 562466, 562469, 562477, 562492, 562496, C07D23364, C07D40312, C07D40912

Patent

active

043473733

ABSTRACT:
This invention relates to a series of compounds having therapeutic activity, consisting of the derivatives obtained by reacting 4-methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole with non-steroidal, traditional, antiinflammatory agents. The derivatives are carboxamides of formula ##STR1## wherein R.sub.1 =H; --CH.sub.3 ; --C.sub.2 H.sub.5 ; and ##STR2## of the antiinflammatory agents, i.e. the acylic radical of the antiinflammatory acid, or ##STR3## of the antiinflammatory acid and the corresponding physiologically acceptable salts on the imidazole ring.

REFERENCES:
patent: 2301532 (1942-11-01), Fell
March, J., Advanced Organic Chemistry, McGraw Hill, New York, 1968, p. 335.

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