Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic age

Details Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic age Derivatives of 4-anilinoquinoline-3-carboxamide as analgesic age

1991-12-23

1995-08-01

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546162, C07D21546, A61K 3147

Patent

active

054380642

ABSTRACT:
Derivatives of 4-anilinoquinoline having the formula: ##STR1## where X is O or H.sub.2 and Z is 1-substituted-4-piperidinylamino or diloweralkylaminoloweralkyl inhibit binding of tritiated bradykinin to guinea pig ileum and inhibit bradykinin-induced writhing in mice. Bradykinin is a nonapeptide formed in plasma as a result of inflammation or injury and produces pain when it binds with pain receptors. A drug which inhibits the binding of bradykinin therefore has analgetic properties.

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patent: 4357333 (1982-11-01), Archibald
patent: 4666924 (1987-05-01), Stout
patent: 4839369 (1989-06-01), Youssefyeh

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